| Identification | Back Directory | [Name]
(+/-)5-HEPE | [CAS]
83952-40-3 | [Synonyms]
(+/-)5-HEPE
(+/-)5-HEPE
FTAGQROYQYQRHF-FCWZHQICSA-N
5-hydroxy-6,8,11,14,17-eicosapentaenoic acid
(+/-)5-HYDROXYEICOSA-6E,8Z,11Z,14Z,17Z-PENTAENOIC ACID
(+/-)-5-HYDROXY-6E,8Z,11Z,14Z,17Z-EICOSAPENTAENOIC ACID
6,8,11,14,17-Eicosapentaenoic acid, 5-hydroxy-, (6E,8Z,11Z,14Z,17Z)- | [Molecular Formula]
C20H30O3 | [MDL Number]
MFCD00171437 | [MOL File]
83952-40-3.mol | [Molecular Weight]
318.45 |
| Chemical Properties | Back Directory | [Boiling point ]
488.0±45.0 °C(Predicted) | [density ]
0.997±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | [form ]
Clear to light-yellow liquid. | [pka]
4.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites. | [Definition]
ChEBI: 5-HEPE is a hydroxyicosapentaenoic acid that consists of 6E,8Z,11Z,14Z,17Z-icosapentaenoic acid with the hydroxy group located at position 5. It has a role as a mouse metabolite. It is a conjugate acid of a 5-HEPE(1-). | [storage]
Store at -20°C |
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