| Identification | Back Directory | [Name]
ambamustine | [CAS]
83996-50-3 | [Synonyms]
Pt 119
Ptt 119
Ptt-119
Ccris 1548
Ambamustine HCl
Ambamustine hydrochloride
L-Methionine, N-(3-(bis(2-chloroethyl)amino)-N-(4-fluoro-L-phenylalanyl)-L-phenylalanyl)-, ethyl ester, monohydrochloride | [Molecular Formula]
C30H41Cl3FN3O4S | [MDL Number]
MFCD01714693 | [MOL File]
83996-50-3.mol | [Molecular Weight]
665.087 |
| Hazard Information | Back Directory | [Description]
Ambamustine, also known as PTT-119, is a novel tripeptide anticancer agent. PTT 119 was demonstrated to have antileukemic activity on murine and human cell lines. Most leukemic cell populations appeared to be responsive to the drug in a dose-related fashion. By cluster analysis, it was possible to discriminate subsets of samples according to PTT 119 sensitivity, and to investigate cross resistance with cytosine arabinoside and daunorubicin. PTT 119 may deserve applications in the treatment of acute nonlymphoblastic leukemia patients. |
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