| Identification | Back Directory | [Name]
Helioxanthin 8-1 | [CAS]
840529-13-7 | [Synonyms]
CS-1213
Helioxanthin 8-1
Helioxanthin analogue 8-1
11-(1,3-Benzodioxol-5-yl)-8,9-dihydro-1,3-benzodioxolo[4,5-g]phthalazine-7,10-dione
1,3-Benzodioxolo[4,5-g]phthalazine-7,10-dione, 11-(1,3-benzodioxol-5-yl)-8,9-dihydro- | [Molecular Formula]
C20H12N2O6 | [MDL Number]
MFCD28167792 | [MOL File]
840529-13-7.mol | [Molecular Weight]
376.32 |
| Chemical Properties | Back Directory | [Melting point ]
318-320 °C | [density ]
1.548±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
10.56±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
helioxanthin 8-1, an analogue of helioxanthin (ach126447), is an inhibitor of hbv and hiv virus with ec50 values of 0.03 μm and 2.7 μm, respectively [1].helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with ec50 values of 0.03 μm and 2.7 μm for hbv and hiv, respectively [1]. in the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis b virus (dhbv) dna synthesis with a mean ic50 value of 0.25±0.05 μm. besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with cc50 values of 18±2 μm and 45±3 μm, respectively, by using an mtt assay [2]. | [storage]
Store at -20°C | [References]
[1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46.
[2] ying c1, tan s, cheng yc. helioxanthin analogue 8-1 inhibits duck hepatitis b virus replication in cell culture. antivir chem chemother. 2010;21(2):97-103. |
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