ChemicalBook--->CAS DataBase List--->848035-21-2

848035-21-2

848035-21-2 Structure

848035-21-2 Structure
IdentificationBack Directory
[Name]

Compound 48/80 (hydrochloride)
[CAS]

848035-21-2
[Synonyms]

C48/80 trihydrochloride
Compound 48/80 (hydrochloride)
[Molecular Formula]

C32H48Cl3N3O3
[MDL Number]

MFCD04108752
[MOL File]

848035-21-2.mol
[Molecular Weight]

629.101
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C, sealed storage, away from moisture ,protect from light
[solubility ]

Water: 100 mM
[form ]

A solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS06
[Signal word ]

Danger
[Hazard statements ]

H301+H311+H331
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P310-P321-P330-P302+P352-P304+P340-P311-P312-P361+P364-P403+P233-P405-P501
Hazard InformationBack Directory
[Biological Activity]

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde condensation products. It is also a histamine releaser and mast cell degranulator. It inhibits the activity of phosphatidylinositol-specific phospholipase C in human platelets.
[in vitro]

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant ) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.

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[in vivo]

Compound 48/80 trihydrochloride (0.75 mg/kg; ip; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.

Animal Model: 7-week-old Wistar male rats (fasted for 24 hours)
Dosage: 0.75 mg/kg
Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h
Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin conc entrations in rats decreased time-dependently thereafter.
[storage]

Store at -20°C, sealed storage, away from moisture ,protect from light
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