| Identification | Back Directory | [Name]
c-GpAp | [CAS]
849214-04-6 | [Synonyms]
cGAMP
c-GpAp
di-GAMP
di-cGAMP
3'3'-cGAMP
Cyclic GMP-AMP
cGAMP ammonium salt
cGAMP (Cyclic GMP-AMP
c-(ApGp) / 3'3'-cGAMP
RFCBNSCSPXMEBK-XRIIRFCZSA-N
3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide
3',3'-Cyclic guanosine monophosphate-adenosine monophosphate | [Molecular Formula]
C20H24N10O13P2 | [MDL Number]
MFCD28411367 | [MOL File]
849214-04-6.mol | [Molecular Weight]
674.41 |
| Chemical Properties | Back Directory | [Boiling point ]
1159.9±75.0 °C(Predicted) | [density ]
2.61±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
0.96±0.70(Predicted) | [color ]
white to beige | [Water Solubility ]
Water : 20 mg/mL (29.66 mM) |
| Hazard Information | Back Directory | [Uses]
c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA. | [Definition]
ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-). | [Biochem/physiol Actions]
cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment. | [storage]
Store at -20°C |
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BOC Sciences
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https://www.bocsci.com |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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