| Identification | Back Directory | [Name]
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE | [CAS]
849461-90-1 | [Synonyms]
TMPH
TMPH HYDROCHLORIDE
2,2,6,6-Tetramethylpiperidin-4-ylheptanoate
Heptanoic acid, 2,2,6,6-tetramethyl-4-piperidinyl ester
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
neurol disorder,nAChR,Nicotinic acetylcholine receptors,neuronal nicotinic receptors,selective inhibition,Inhibitor,inhibit,nicotinic receptor,brain function,tetramethylpiperidinyl heptanoate,dysfunction | [Molecular Formula]
C16H31NO2 | [MDL Number]
MFCD08277030 | [MOL File]
849461-90-1.mol | [Molecular Weight]
269.42 |
| Hazard Information | Back Directory | [Uses]
TMPH Hydrochloride is a potent inhibitor of neuronal AChRs. Therapeutic agent potentially used for the treatment of this progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease. | [Definition]
ChEBI: Heptanoic acid (2,2,6,6-tetramethyl-4-piperidinyl) ester is a fatty acid ester. | [Biological Activity]
Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α 3, α 4 and β 2, β 4 respectively). Displays little inhibition of muscle-type ( α 1 β 1 γ δ ) or α 7 receptors. |
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