| Identification | Back Directory | [Name]
15(R)-ILOPROST | [CAS]
85026-51-3 | [Synonyms]
15(R)-ILOPROST
HIFJCPQKFCZDDL-GAGQTBDJSA-N
15(R)-IloprostQ: What is
15(R)-Iloprost Q: What is the CAS Number of
15(R)-Iloprost
6,9ALPHA-METHYLENE-11ALPHA,15R-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID
Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-, (5E)- (9CI) | [Molecular Formula]
C22H32O4 | [MDL Number]
MFCD05863932 | [MOL File]
85026-51-3.mol | [Molecular Weight]
360.49 |
| Hazard Information | Back Directory | [Description]
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM. 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost. |
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