| Identification | Back Directory | [Name]
Rilmenidine-d4 | [CAS]
85047-14-9 | [Synonyms]
Rilmenidine-d4
4,4,5,5-tetradeuterio-N-(dicyclopropylmethyl)-1,3-oxazol-2-amine
Rilmenidine D4Q: What is
Rilmenidine D4 Q: What is the CAS Number of
Rilmenidine D4 Q: What is the storage condition of
Rilmenidine D4 Q: What are the applications of
Rilmenidine D4 | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C10H12D4N2O | [MOL File]
85047-14-9.mol | [Molecular Weight]
184.271 |
| Hazard Information | Back Directory | [Biological Activity]
Rilmenidine-d4 is intended for use as an internal standard for the quantification of rilmenidine by GC- or LC-MS. Rilmenidine is an antihypertensive agent.1 It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.2 Rilmenidine (1 μM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.3 Formulations containing rilmenidine have been used in the treatment of hypertension. | [References]
1.Gomez, R.E., Ernsbarger, P., Feinland, G., et al.Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 areaEur. J. Pharmacol.195(2)181-191(1991)
2.Burke, S.L., Evans, R.G., and Head, G.A.Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertensionJ. Hypertens.29(5)945-952(2011)
3.Williams, A., Sarkar, S., Cuddon, P., et al.Novel targets for Huntington's disease in an mTOR-independent autophagy pathwayNat. Chem. Biol.4(5)295-305(2008)
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