| Identification | Back Directory | [Name]
RSM932A | [CAS]
850807-63-5 | [Synonyms]
TCD717
RSM932A
TCD 717
TCD-717.
RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.
1,1''-([1,1''-Biphenyl]-4,4''-diylbis(methylene))bis(4-(methyl(p-tolyl)amino)quinolin-1-ium) bromide | [Molecular Formula]
C46H38BrCl2N4+ | [MDL Number]
MFCD29058562 | [MOL File]
850807-63-5.mol | [Molecular Weight]
797.64 |
| Chemical Properties | Back Directory | [Melting point ]
255-257 °C | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 3 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml | [form ]
A crystalline solid | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
RSM-932A is a selective inhibitor of choline kinase α (CHOKα; IC50s = 1 and >50 μM for CHOKα and β, respectively). It induces apoptosis via CHOP signaling and endoplasmic reticulum (ER) stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells, but it only induces cell cycle arrest and not apoptosis in NCM460 and MCF-10A normal epithelial cells. RSM-932A inhibits the growth of HT-29 colon cancer cells in vitro (IC50 = 1.15 μM) and in vivo in a mouse xenograft model (ED50 = 7.5 mg/kg). |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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