ChemicalBook--->CAS DataBase List--->852230-33-2

852230-33-2

852230-33-2 Structure

852230-33-2 Structure
IdentificationBack Directory
[Name]

ML-031
[CAS]

852230-33-2
[Synonyms]

ML-031
CYM-5482
1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione
[Molecular Formula]

C19H20N2O3
[MDL Number]

MFCD06675163
[MOL File]

852230-33-2.mol
[Molecular Weight]

324.374
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

≤5mg/ml in ethanol;5mg/ml in DMSO
[form ]

crystalline solid
Hazard InformationBack Directory
[Definition]

ChEBI: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-oxoethyl]pyrrolidine-2,5-dione is an aromatic ketone.
[Biological Activity]

ml-031 is an agonist of s1p2 with ec50 value of 1 μm [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. sphingolipids belong to a family of bioactive molecules with cell signaling properties. sphingosine 1-phosphate (s1p) is widely expressed on various tissues and cell types. s1p is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. until now, five sphingosine-1-phosphate receptors (s1pr1-s1pr5) have been identified. s1pr4 and s1pr5 are prominently expressed in the immune and nervous systems, respectively. s1p functions by binding to five distinct g protein-coupled receptors, s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8.ml-031 activated s1p2 with an ec50 value of 1 μm in a s1p reporter assay [1].
[References]

[1] satsu h, schaeffer m t, guerrero m, et al. a sphingosine 1-phosphate receptor 2 selective allosteric agonist[j]. bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.
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