| Identification | Back Directory | [Name]
(R)-PK11195 | [CAS]
85340-56-3 | [Synonyms]
RP 52028
PK 11195
(R)-PK11195
1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE-(R)
3-ISOQUINOLINECARBOXAMIDE, 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-, (R) | [Molecular Formula]
C21H21ClN2O | [MDL Number]
MFCD02102012 | [MOL File]
85340-56-3.mol | [Molecular Weight]
352.86 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellowish oil | [Uses]
PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells. | [Definition]
ChEBI: PK-11195 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine It has a role as an antineoplastic agent. It is a member of isoquinolines, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes. |
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