| Identification | Back Directory | [Name]
SK&F 89976-A | [CAS]
85375-85-5 | [Synonyms]
SKF-89976
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid | [Molecular Formula]
C22H25NO2 | [MDL Number]
MFCD01321071 | [MOL File]
85375-85-5.mol | [Molecular Weight]
335.44 |
| Hazard Information | Back Directory | [Description]
SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo. | [Definition]
ChEBI: 1-(4,4-diphenylbut-3-enyl)-3-piperidinecarboxylic acid is a diarylmethane. |
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