| Identification | Back Directory | [Name]
VU0238441 | [CAS]
85511-68-8 | [Synonyms]
VU0238441
7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-2,3-dione
7-Chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indole-2,3-dione
1H-Indole-2,3-dione, 7-chloro-1-[[4-(trifluoroMethyl)phenyl]Methyl]- | [Molecular Formula]
C16H9ClF3NO2 | [MDL Number]
MFCD18642601 | [MOL File]
85511-68-8.mol | [Molecular Weight]
339.7 |
| Chemical Properties | Back Directory | [Boiling point ]
441.7±55.0 °C(Predicted) | [density ]
1.500±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: 125 mg/mL (367.97 mM) | [form ]
Solid | [pka]
-3?+-.0.20(Predicted) | [color ]
Brown to red |
| Hazard Information | Back Directory | [Uses]
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2]. | [Biological Activity]
VU0238441 is a positive allosteric modulator (PAM) of pan-muscarinic acetylcholine receptor (mAChR) with EC50 values of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > for M5, M3, M2, M1 and M4, respectively 10 μM. | [in vitro]
VU0238441 is an analogue of VU0119498. | [target]
| Target | Value | mAChR M5
(Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 2.1 μM mAChR M3
(Cell-free assay) | 2.2 μM | mAChR M2
(Cell-free assay) | 2.8 μM | mAChR M1
(Cell-free assay) | 3.2 μM | mAChR M4
(Cell-free assay) | >10 μM |
| [References]
[1] Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. DOI:10.1016/j.bmcl.2009.11.089
[2] Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8. DOI:10.1021/jm900286j |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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