| Identification | Back Directory | [Name]
Epoxy Fluor 7 | [CAS]
863223-43-2 | [Synonyms]
Epoxy Fluor 7
Epoxy Fluor 7 Exclusive
[cyano-(6-methoxynaphthalen-2-yl)methyl] (3-phenyloxiran-2-yl)methyl carbonate
Carbonic acid, cyano(6-methoxy-2-naphthalenyl)methyl [(2R,3R)-3-phenyl-2-oxiranyl]methyl ester, rel- | [Molecular Formula]
C23H19NO5 | [MOL File]
863223-43-2.mol | [Molecular Weight]
389.4 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C,protect from light | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity.1 Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.2,3 Epoxy fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used to monitor the activity of both human and mouse enzymes.4 Hydrolysis of the substrate epoxide yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. Epoxy fluor 7 is more stable in aqueous solution and offers about 2-fold better sensitivity than previously used colorimetric substrates such as NEPC.4 | [storage]
Store at -20°C,protect from light | [References]
1. Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids Circ. Res. 87(11),992-998(2000).
2. Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension Hypertension 46(2),975-981(2005).
3. Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation Proc. Natl. Acad. Sci. USA 102(28),9772-9777(2005).
4. Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies Anal. Biochem. 343,66-75(2005). |
|
|