863774-58-7

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863774-58-7 Structure

Identification	Back Directory
[Name] Dimethylenastron
[CAS] 863774-58-7
[Synonyms] enastron Dimethylenastron Eg5 Inhibitor III Eg5 Inhibitor III(Dimethylenastron) Dimethylenastron - Eg5 inhibitor III Eg5 Inhibitor III, Dimethylenastron - CAS 863774-58-7 - Calbiochem 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone 4-(3-Hydroxyphenyl)-7,7-dimethyl-2-thioxo-2,3,4,6,7,8-hexahydroquinazolin-5(1H)-one 5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-
[Molecular Formula] C16H18N2O2S
[MDL Number] MFCD09264157
[MOL File] 863774-58-7.mol
[Molecular Weight] 302.39

Chemical Properties	Back Directory
[Boiling point ] 475.6±55.0 °C(Predicted)
[density ] 1.34±0.1 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] DMSO: soluble15mg/mL, clear
[form ] powder
[pka] 9.59±0.10(Predicted)
[color ] white to beige

Safety Data	Back Directory
[Symbol(GHS) ] GHS07,GHS08,GHS09
[Signal word ] Danger
[Hazard statements ] H315-H319-H360-H410
[Precautionary statements ] P501-P273-P202-P201-P264-P280-P302+P352-P391-P308+P313-P337+P313-P305+P351+P338-P362+P364-P332+P313-P405
[WGK Germany ] 3

Hazard Information	Back Directory
[Uses] Dimethylnasetron is an inhibitor of mitotic motor kinesin Eg5, triggering apoptosis and upregulates Hsp-70 in human myeloma cells.
[Biochem/physiol Actions] Dimethylenastron is specific, reversible inhibitor of the mitotic motor kinesin Eg5. Dimethylenastron inhibits bipolar spindle formation, and inhibits proliferation, migration and invasion of several pancreatic cancer cell lines in cell based assays.
[in vivo] Dimethylenastron (1.0 μmol) induces a milder scarring but the length of bleb survival is not significantly prolonged compared with the control group. Dimethylenastron (1.0 μmol) reveals a markedly reduced ratio of intraocular pressure and a milder, but not obviously reduced, subconjunctival fibrotic reaction in the rabbits treated with glaucoma filtration surgery^[3].
[IC 50] Eg5: 200 nM (IC₅₀)
[storage] Store at -20°C

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