ChemicalBook--->CAS DataBase List--->86482-18-0

86482-18-0

86482-18-0 Structure

86482-18-0 Structure
IdentificationBack Directory
[Name]

Timentin
[CAS]

86482-18-0
[Synonyms]

TIMENTIN
TIMENTIN
TIMENTIN
TIMENTIN
Temetine
ticarcillin-clavulanic acid
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid:(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
[Molecular Formula]

C15H16N2O6S2.C8H9NO5
[MDL Number]

MFCD01710900
[MOL File]

86482-18-0.mol
[Molecular Weight]

583.593
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Antimicrobial activity]

Activity is that of ticarcillin , the role of the inhibitor being to restore the activity against β-lactamase-producing strains that would otherwise hydrolyze the drug.
[Pharmacokinetics]

Cmax 3 g ticarcillin + 100 mg: 330 mg/L end: 8 mg/L end
clavulanate intravenous: infusion: infusion
infusion (30 min)
Plasma half-life: 1.1 h 1.1 h
Plasma protein binding: 45% 25%
The pharmacokinetics of the two agents are mutually unaffected by co-administration. Ticarcillin can be detected in tissues and interstitial fluid following parenteral administration. Penetration into bile, peritoneal fluid and pleural fluid has been demonstrated. Concentrations in blister fluid were significantly lower than those in serum.
Around 60–70% of ticarcillin and 35–45% of clavulanic acid are excreted unchanged in urine during the first 6 h after administration of a single dose of the mixture.
[Clinical Use]

Septicemia, including bacteremia
Lower respiratory infections
Bone and joint infections
Skin and skin structure infections
Urinary tract infections (complicated and uncomplicated)
Gynecological infections, endometritis
Intra-abdominal infections, peritonitis
Its main use is in infections in which Ps. aeruginosa is suspected or proven.
[Side effects]

Adverse reactions associated with ticarcillin occur . As with co-amoxiclav, there is a risk of cholestatic jaundice . Pseudomembranous colitis has been reported.
86482-18-0 suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501 , +undefined18621343501
Website: www.acmec.com.cn/
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580 , +8613817748580
Website: www.kean-chem.com
Company Name: AILY INTL CHEMICAL CORP LTD  Gold
Tel: 025-83208295 18913388297
Website: www.chemicalbook.com/showsupplierproductslist15679/0.htm
Company Name: Hubei wei shi reagent group ltd., company  Gold
Tel: 027-59102966 18717199209
Website: www.4008081911.com
Company Name: Adamas Reagent, Ltd.  
Tel: 400-6009262 16621234537
Website: http://www.tansoole.com
Company Name: Shanghai Macklin Biochemical Co.,Ltd.  
Tel: 15221275939 15221275939
Website: www.macklin.cn
Company Name: Chizhou Kailong Import and Export Trade Co., Ltd.  
Tel:
Website: www.chemicalbook.com/ShowSupplierProductsList16778/0.htm
Company Name: Hubei widely chemical technology Co., Ltd.  
Tel: 027-59402396 13419635609
Website: http://www.wislmanbio.com/
Company Name: Anhui kuer Bioengineering Co., Ltd  
Tel: 0551-65171243 13856024262
Website: http://www.kuerhuaxue.com
Company Name: Hubei widely chemical technology Co., Ltd.  
Tel: 027-83778895 18602735115
Website: http://www.hbwidely.cn
Company Name: Hefei Bomei Biotechnology Co., Ltd.  
Tel: 13856598764
Website: http://www.bomeibio.com
Company Name: Wuhan Dingtong Pharmaceutical Co., Ltd  
Tel: 027-59207795 18327179646
Website: www.chemicalbook.com/showsupplierproductslist1732734/0.htm
Company Name: Hubei widely chemical technology Co., Ltd.  
Tel: 027-83989310 18627915365
Website: http://www.widelychemical.com
Company Name: Wuhan Dingxintong Pharmaceutical Co. , Ltd.  
Tel: 027-83984790 17720532645
Website: https://www.chemicalbook.com/supplier/23506343/
Company Name: Wuhan Dingxintong Pharmaceutical Co. , Ltd.  
Tel: 027-027-52344656 15871722230
Website: https://show.guidechem.com/dxt2019/
Company Name: Lingyuan Bebiansen Biological Technology Co., Ltd  
Tel: 18642120371
Website: https://www.bebiosion.com/
Company Name: Nantong Feiyu Biological Technology CO.,LTD  
Tel: 0513-68819626; 15152877458
Website: http://www.feiyubio.com/
Tags:86482-18-0 Related Product Information
25953-19-9 34787-01-4