| Identification | Back Directory | [Name]
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- | [CAS]
865305-30-2 | [Synonyms]
Ro 4
AF 353
CS-2469
CHEMBL526307
AF-353 (Ro-4)
CHEMBL526307;AF 353;AF353
5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride | [Molecular Formula]
C14H17IN4O2 | [MDL Number]
MFCD18782750 | [MOL File]
865305-30-2.mol | [Molecular Weight]
400.21 |
| Chemical Properties | Back Directory | [Boiling point ]
510.2±60.0 °C(Predicted) | [density ]
1.619±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 32 mg/mL (79.96 mM) | [form ]
Solid | [pka]
6.89±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively).1,2 It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all).2 It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.3 |
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