86636-92-2

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86636-92-2 Structure

Identification	Back Directory
[Name] 6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE
[CAS] 86636-92-2
[Synonyms] ACRYLODAN 6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE 1-(6-Dimethylamino-naphthalen-2-yl)-propenone Acrylodan [6-Acryloyl-2-dimethylaminophthalene] ACRYLODAN [6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE] 1-(6-(Dimethylamino)-2-naphthalenyl)-2-propen-1-one 1-(6-(Dimethylamino)naphthalen-2-yl)prop-2-en-1-one 2-Propen-1-one, 1-(6-(dimethylamino)-2-naphthalenyl)-
[Molecular Formula] C15H15NO
[MDL Number] MFCD00467545
[MOL File] 86636-92-2.mol
[Molecular Weight] 225.29

Chemical Properties	Back Directory
[Melting point ] 130-131 °C(Solv: ethanol (64-17-5); water (7732-18-5))
[Boiling point ] 388.3±24.0 °C(Predicted)
[density ] 1.100±0.06 g/cm3(Predicted)
[storage temp. ] Sealed in dry,2-8°C
[form ] Solid
[pka] 4.32±0.40(Predicted)
[color ] Light yellow to yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Information	Back Directory
[Uses] Acrylodan, reacted with thiols, is sensitive to the local environmental dipolarity and dynamics within the binding pocket surrounding Cys34[1][2].
[References] [1] Sarah F Stuart, et al. A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin. J Biol Chem. 2011 Jan 7;286(1):178-84. DOI:10.1074/jbc.M110.166256 [2] K Flora, et al. Unfolding of acrylodan-labeled human serum albumin probed by steady-state and time-resolved fluorescence methods. Biophys J. 1998 Aug;75(2):1084-96. DOI:10.1016/S0006-3495(98)77598-8

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