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86696-87-9

86696-87-9 Structure

86696-87-9 Structure
IdentificationBack Directory
[Name]

Aganodine
[CAS]

86696-87-9
[Synonyms]

Aganodin
Aganodine
Guanidine, N-(4,7-dichloro-1,3-dihydro-2H-isoindol-2-yl)-
[Molecular Formula]

C9H10Cl2N4
[MDL Number]

MFCD00864139
[MOL File]

86696-87-9.mol
[Molecular Weight]

245.112
Hazard InformationBack Directory
[Originator]

Aganodine ,ZYF Pharm Chemical
[Manufacturing Process]

The solution of 3,6-dichlorophthalic anhydride in 300 ml of N,Ndimethylformamide are heated to the boiling point over 15 min with tbutylcarbazate. Subsequent to evaporation of the solvent, N-(tbutyloxycarbonylamino)- 3,6-dichlorophthalimide is obtained from ethanol.
The solution of N-(t-butyloxycarbonylamino)-3,6-dichlorophthalimide in 400 ml of absolute tetrahydrofuran are slowly dripped into a suspension of aluminum lithium hydride in absolute tetrahydrofuran. The mixture is heated to the boiling point. Conventional processing yields N-(t-butyloxycarbonylamino)-4,7- dichloroisoindoline.
N-(t-Butyloxycarbonylamino)-4,7-dichloroisoindoline are introduced into concentrated hydrochloric acid and stirred at room temperature. The hydrochloride of 2-amino-4,7-dichloroisoindoline precipitates in the form of crystals is obtained, melting point 230°-232°C.
2-Amino-4,7-dichloroisoindoline hydrochloride and cyanamide are heated over 2 h to the boiling point in n-amyl alcohol. The solvent is evaporated off and the residue recrystallized from isopropyl alcohol and ethyl ether, yielding the (4,7-dichloroisoindolin-2-yl)guanidine in the form of hydrochloride, melting point 235°-237°C.
To obtained the base (4,7-dichloroisoindolin-2-yl)guanidine the salt (4,7- dichloroisoindolin-2-yl)guanidine hydrochloride is treated with sodium bicarbonicum.
[Therapeutic Function]

Antihypertensive
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