| Identification | Back Directory | [Name]
(8,9-DiHETE | [CAS]
867350-87-6 | [Synonyms]
(8,9-DiHETE
8,9-dihydroxy-5(Z),11(Z),14(Z),17(Z)-eicosatetraenoic acid | [Molecular Formula]
C20H32O4 | [MOL File]
867350-87-6.mol | [Molecular Weight]
336.466 |
| Hazard Information | Back Directory | [Description]
(±)8(9)-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid (EPA; ).1 It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases.1 Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.2 | [Definition]
ChEBI: 8,9-DiHETE is a hydroxy fatty acid and a polyunsaturated fatty acid. | [References]
1. VanRollins, M., Frade, P.D., and Carretero, O.A. Oxidation of 5,8,11,14,17-eicosapentaenoic acid by hepatic and renal microsomes Biochim. Biophys. Acta 996,133-149(1988).
2. Knapp, H.R., Miller, A.J., and Lawson, J.A. Urinary excretion of diols derived from eicosapentaenoic acid during N-3 fatty acid ingestion Prostaglandins 42,47-53(1991). |
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