| Identification | Back Directory | [Name]
RO0335 | [CAS]
867365-76-2 | [Synonyms]
RO0335
depulfavirine
1,10-phenanthroline-6-carboxylicacid
5-methylsulfonylpyridine-4-carbonitrile
N-[4-(Aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorobenzeneacetamide
Benzeneacetamide, N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-
Reverse Transcriptase,RO0335,RO 0335,nonnucleoside,novel,inhibit,diphenylether,potent,HIV-1,Ro-0335,Inhibitor | [Molecular Formula]
C21H13BrCl2FN3O4S | [MOL File]
867365-76-2.mol | [Molecular Weight]
573.22 |
| Hazard Information | Back Directory | [Uses]
RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1]. | [References]
[1] Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86(2):212-219. DOI:10.1016/j.antiviral.2010.02.323 |
|
| Company Name: |
DebyeTec.com Inc.
|
| Tel: |
18086626237 18086626237 |
| Website: |
https://www.debyetec.com |
|