| Identification | Back Directory | [Name]
Benzyl-PEG8-azide | [CAS]
868594-42-7 | [Synonyms]
Benzyl-PEG7-N3
Benzyl-PEG8-N3
Benzyl-PEG8-azide
Benzyl-PEG7-azide | [Molecular Formula]
C21H35N3O7 | [MOL File]
868594-42-7.mol | [Molecular Weight]
441.53 |
| Hazard Information | Back Directory | [Biological Activity]
Benzyl-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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