| Identification | Back Directory | [Name]
vanoxonin | [CAS]
86933-99-5 | [Synonyms]
vanoxonin
MG-245-CF2-A
Antibitic MG-245CF2A
Antibiotic MG 245CF2A
(+)-N-(2,3-Dihydroxybenzoyl)-L-Thr-N5-Ac-N5-hydroxy-L-Orn-OH
N5-Acetyl-N2-[N-(2,3-dihydroxybenzoyl)-L-threonyl]-N5-hydroxy-L-ornithine | [Molecular Formula]
C18H25N3O9 | [MDL Number]
MFCD01939818 | [MOL File]
86933-99-5.mol | [Molecular Weight]
427.408 |
| Hazard Information | Back Directory | [Biological Activity]
Vanoxonin is a bacterial metabolite that has been found in S. hirsuta.1 It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 μg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 μg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models. | [storage]
-20°C | [References]
1.Kanai, F., Sawa, T., Hamada, M., et al.Vanoxonin, a new inhibitor of thymidylate synthetaseJ. Antibiot. (Tokyo)36(6)656-660(1983)
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