| Identification | Back Directory | [Name]
THP-PEG7-OH | [CAS]
873110-21-5 | [Synonyms]
THP-PEG7-OH
OH-PEG7-THP
3,6,9,12,15,18-Hexaoxaeicosan-1-ol, 20-[(tetrahydro-2H-pyran-2-yl)oxy]- | [Molecular Formula]
C19H38O9 | [MDL Number]
MFCD29059860 | [MOL File]
873110-21-5.mol | [Molecular Weight]
410.5 |
| Hazard Information | Back Directory | [Biological Activity]
THP-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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