| Identification | Back Directory | [Name]
1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester | [CAS]
877399-73-0 | [Synonyms]
Crizotinib Impurity 16
1-(4-BOC-piperidyl)-4-iodopyrazole
1-(4-BOC-piperazino)-4-iodopyrazole
1-(1-Boc-4-piperidinyl)-4-iodopyrazole
1-Boc-4-(4-iodo-1H-pyrazol-1-yl)piperidine
tert-Butyl 4-(4-iodopyrazolyl)piperidinecarboxylate
1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-
tert-butyl 4-(4-iodopyrazol-1-yl)piperidine-1-carboxylate
tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
4-(4-Iodo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester
1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H20IN3O2 | [MDL Number]
MFCD12913927 | [MOL File]
877399-73-0.mol | [Molecular Weight]
377.22 |
| Chemical Properties | Back Directory | [Melting point ]
97 °C | [Boiling point ]
430.6±35.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
Solid | [pka]
1.08±0.19(Predicted) | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Synthesis]
1-(4-BOC-piperidyl)-4-iodopyrazole is prepared by the reaction of 4-Iodopyrazole and 1-Boc-4-methanesulfonyloxypiperidine. The specific synthesis steps are as follows:
To a stirred solution of 4-iodo-lH-pyrazole (8.98 g, 46.28 mmol) in DCM (160 mL) was added NaH (1.67 g, 55.53 mmol, 80percent NaH/mineral oil) portion-wise at 0 °C. The mixture was stirred at 0 °C for 1 hour, then tert-butyl 4-((methylsulfonyl)oxy)piperidine-l- carboxylate (14.22 g, 50.90 mmol) was added. The resulted mixture was stirred at 100 °C for 15 hours, then cooled to rt, quenched with H20 (30 mL) and concentrated in vacuo. The residue was diluted with H20 (150 mL), and the mixture was extracted with EtOAc (100 mL x 5). The combined organic layers were dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 5/1) to give 1-(4-BOC-piperidyl)-4-iodopyrazole as a white solid (12.25 g, 70.2percent>). MS (ESI, pos. ion) m/z: 322.0 (M-56+1).
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