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87862-25-7

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87862-25-7 Structure

87862-25-7 Structure
IdentificationBack Directory
[Name]

3-IODOBENZYL-GUANIDINE HEMISULFATE
[CAS]

87862-25-7
[Synonyms]

M-IBG
MIBG hemisulfate
MIBG HEMISULFATE SALT
m-iodobenzylguanidine sulfate
M-IODOBENZYLGUANIDINE 1/2H2SO4
3-IODOBENZYLGUANIDINE HEMISULPHATE
3-IODOBENZYL-GUANIDINE HEMISULFATE
meta-Iodobenzylguanidine hemisulfate
M-IODOBENZYLGUANIDINE HEMISULFATE SALT
Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1)
[Molecular Formula]

C16H22I2N6O4S
[MDL Number]

MFCD00151189
[MOL File]

87862-25-7.mol
[Molecular Weight]

648.26
Chemical PropertiesBack Directory
[Appearance]

Colourless to off-white solid
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Chemical Properties]

Colourless to off-white solid
[Description]

m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity. It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 μg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors. MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes.
[Uses]

m-Iodobenzylguanidine Hemisulfate?can be used to demethylate and oxidize membrane-associated DNA. It has also been employed to develop a cell-based high-throughput screening assay to identify anti-hepatitis C virus compounds.
[Biochem/physiol Actions]

Antitumor agent which inhibits ADP ribosylation.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[WGK Germany ]

3
[HS Code ]

2909309090
Spectrum DetailBack Directory
[Spectrum Detail]

3-IODOBENZYL-GUANIDINE HEMISULFATE(87862-25-7)1HNMR
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