| Identification | Back Directory | [Name]
Δ2-Cefepime | [CAS]
88040-25-9 | [Synonyms]
Δ2-Cefepime
Δ2-Cefepime
Δ2-CefepiMe Etherate
Cefepime Δ - 3 Isomer
Cefepime Δ - 3 Isomer
Δ2-CefepiMe Etherate Dihydrochloride Salt
1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-en-3-yl]Methyl]-1-MethylpyrrolidiniuM Inner Salt Etherate
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate,ethoxyethane | [Molecular Formula]
C23H34N6O6S2 | [MOL File]
88040-25-9.mol | [Molecular Weight]
554.683 |
| Chemical Properties | Back Directory | [Melting point ]
>151°C (dec.) | [storage temp. ]
Amber Vial, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C19H24N6O5S2.C4H10O/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;1-3-5-4-2/h8-9,13-14,17H,3-7H2,1-2H3,(H3-,20,21,22,26,28,29);3-4H2,1-2H3/b23-12-;/t13-,14?,17-;/m1./s1 | [InChIKey]
DBCVQAGQPYVVDA-XVKMNWMGSA-N | [SMILES]
S1C([H])=C(C([H])(C(=O)[O-])N2C([C@]([H])([C@@]12[H])N([H])C(/C(/C1=C([H])SC(N([H])[H])=N1)=N\OC([H])([H])[H])=O)=O)C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H].O(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Solid | [Uses]
The Δ2-isomer of Cefepime (C242750), a new series of cephalosporins. | [Uses]
Δ2-Cefepime is the Δ2-isomer of Cefepime (C242750), a new series of cephalosporins. | [Preparation]
First, cefepime and N-trimethylsilylacetamide were added to dichloromethane for 0.5 h. Subsequently, triethylamine dissolved in dichloromethane was added to the reaction system between 2-5 °C. Adjust the temperature to 2-5 °C and react for 24 h. After adding water, the aqueous layer was separated, and the aqueous phase was washed with methylene chloride. Wait for the solution to cool to 2-5 °C and adjust the pH=3 with sulfuric acid. Stir the resulting slurry for 2h. Filter to collect the solids and wash with water, adjust the pH=7.5-8.0 with sodium bicarbonate aqueous solution, add carbon, and stir for 30 min. Filter the mixture to collect the filtrate and adjust pH=3 with sulfuric acid. Finally, the solids are filtered and collected, and product Δ2-Cefepime is obtained by washing and drying.
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