| Identification | Back Directory | [Name]
HIF-2a Translation Inhibitor 76 | [CAS]
882268-69-1 | [Synonyms]
HIF-2α-IN-4
HIF-2a translation inhibitor
HIF-2a Translation Inhibitor 76 | [Molecular Formula]
C9H9N3O4S2 | [MDL Number]
MFCD30861484 | [MOL File]
882268-69-1.mol | [Molecular Weight]
287.32 |
| Chemical Properties | Back Directory | [Boiling point ]
454.3±55.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
5.38±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1].
HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1]. | [References]
[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848. |
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BOC Sciences
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https://www.bocsci.com |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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