| Identification | Back Directory | [Name]
PIRIPROST POTASSIUM SALT | [CAS]
88851-62-1 | [Synonyms]
U-60257B
U60,257B POTASSIUM SALT
PIRIPROST POTASSIUM SALT
potassium:5-[(4R,5R)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-1-phenyl-5,6-dihydro-4H-cyclopenta[b]pyrrol-2-yl]pentanoate
1,4(R),5(R),6-TETRAHYDRO-5-HYDROXY-4-[(1E,3S)-HYDROXY-1-OCTENYL]-1-PHENYL-CYCLOPENTA[B]PYRROLE-2-PENTANOIC ACID, MONOPOTASSIUM SALT
[4R-[4A(1E,3S*),5B]]-1,4,5,6-TETRAHYDRO-5-HYDROXY-4-(3-HYDROXY-1-OCTENYL)-1-PHENYL-CYCLOPENTA[B]PYRROLE-2-PENTANOIC ACID, POTASSIUM SALT
[4r-[4α(1e,3s*),5β]]-1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, potassium salt
U60,257B, [4R-[4α(1E,3S*),5β]]-1,4,5,6-Tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, potassium salt | [Molecular Formula]
C26H34KNO4 | [MDL Number]
MFCD02259346 | [MOL File]
88851-62-1.mol | [Molecular Weight]
463.65 |
| Hazard Information | Back Directory | [Uses]
Antiasthmatic. | [Uses]
Piriprost Potassium is a structural analog of prostaglandin I2. | [Biological Activity]
piriprost (u 60257) is a leukotriene synthesis inhibitor [1].leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. leukotrienes mainly act on a subfamily of g protein-coupled receptors. the production of leukotrienes is implicated in triggerring contractions in the smooth muscles lining the bronchioles and is a major cause of inflammation in asthma and allergic rhinitis [2].piriprost inhibited the formation of 5-hydroxyeicosatetraenoic acid (5-hete), ltb4, and the sulfidopeptide leukotrienes with the ic50 values ranged from 9 to 14 μm for the mouse mast cells and 15-50 μm for the basophil leukemia cells. piriprost weakly inhibited the solubilized ltc synthase of rat basophil leukemia cells with the ic50 of 1.5 mm [1]. piriprost increased alkaline phosphatase (alp) activity in cultured endometrial stromal cells. piriprost (100 μm) inhibited 5-lipoxygenase activity and decreased 5-hydroxy-eicosatetraenoic acid (a 5-lipoxygenase product) by 53% [3].in smoke-exposed rabbits, pretreatment with piriprost attenuated the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type i alveolar epithelium [4]. | [storage]
Store at -20°C | [References]
[1] bach m k, brashler j r, white g j, et al. experiments on the mode of action of piriprost (u-60,257), an inhibitor of leukotriene formation in cloned mouse mast cells and in rat basophil leukemia cells[j]. biochemical pharmacology, 1987, 36(9): 1461-1466.
[2] smith m j h, ford‐hutchinson a w, bray m a. leukotriene b: a potential mediator of inflammation[j]. journal of pharmacy and pharmacology, 1980, 32(1): 517-518.
[3] cejic s s, kennedy t g. examination of the effects of piriprost (u-60,257 b) on alkaline phosphatase activity of rat endometrial stromal cells in vitro[j]. prostaglandins, 1991, 42(2): 179-189.
[4] itten m l, grad r, quan s f, et al. piriprost pretreatment attenuates the smoke-induced increase in 99mtcdtpa lung clearance[j]. experimental lung research, 1990, 16(4): 339-353. |
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