| Identification | Back Directory | [Name]
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol | [CAS]
88930-15-8 | [Synonyms]
Mogrol
Mogrol, >98%
(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene | [Molecular Formula]
C30H52O4 | [MDL Number]
MFCD29904541 | [MOL File]
88930-15-8.mol | [Molecular Weight]
476.73 |
| Chemical Properties | Back Directory | [Boiling point ]
595.6±50.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.67±0.29(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
88930-15-8 |
| Hazard Information | Back Directory | [Definition]
ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol. | [Biochem/physiol Actions]
Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells. | [storage]
Store at -20°C |
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