| Identification | Back Directory | [Name]
AMG-51 | [CAS]
890019-63-3 | [Synonyms]
AMG-51
AMG-51 (KRC547)
2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one
5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one | [Molecular Formula]
C34H33F2N5O5 | [MOL File]
890019-63-3.mol | [Molecular Weight]
629.65 |
| Hazard Information | Back Directory | [Enzyme inhibitor]
This protein kinase inhibitor (FW = 629.65 g/mol; CAS 890019-63-3; Solubility: 15 mM in DMSO), also known as 5-(3-fluoro-4-(6-methoxy-7- (3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one, targets c-Met, or hepatocyte growth factor receptor (HGFR), a protein tyrosine kinase that plays a key role in several cellular processes and is overexpressed or mutated in different human cancers. AMG-51 shows the enzyme selectivity of c-Met with a (Ki = 4.9 nM), with off-targets, such as IGFR (Ki = 22nM), Ron or Recepteur d'Origine Nantais kinase (Ki = 28nM), and KDR (Ki = 139 nM). |
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Lynnchem
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Novachemistry
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Creative Enzymes
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