| Identification | Back Directory | [Name]
BGG463 | [CAS]
890129-26-7 | [Synonyms]
BGG463
K 0859
CS-2570
K 03859
BGG 463;BGG-463
BGG463 (K03859)
6-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide | [Molecular Formula]
C30H29F3N6O3 | [MDL Number]
MFCD31618015 | [MOL File]
890129-26-7.mol | [Molecular Weight]
578.58 |
| Chemical Properties | Back Directory | [Boiling point ]
669.0±55.0 °C(Predicted) | [density ]
1.366±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (216.05 mM) | [form ]
Solid | [pka]
12.06±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BGG463 (K03859) is an orally active type II CDK2 inhibitor[1]. | [Biological Activity]
BGG463 (K03859) is an orally active inhibitor of type II CDK2. | [in vitro]
BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML. | [target]
| [IC 50]
CDK2 | [storage]
Store at -20°C | [References]
[1] Alexander LT, et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25. DOI:10.1021/acschembio.5b00398
[2] Jones K, et al. Cancer Drug Discovery 2010: from molecules to medicine. Expert Rev Clin Pharmacol. 2010 Sep;3(5):613-5. DOI:10.1586/ecp.10.50 |
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