| Identification | Back Directory | [Name]
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE | [CAS]
89196-95-2 | [Synonyms]
2-BFI HCL
2-BFI HYDROCHLORIDE
2-BFI hydrochlorid
(2 BFI hydrochloride
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride | [Molecular Formula]
C11H11ClN2O | [MDL Number]
MFCD00672666 | [MOL File]
89196-95-2.mol | [Molecular Weight]
222.67 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: 20mg/mL, clear | [form ]
White powder. | [color ]
White to off-white | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride is a I2 receptor agonists that induces hypothermic effect in rats. | [Biological Activity]
High affinity I 2 ligand (K i = 9.8 nM). Putative I 2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract. | [in vivo]
RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2]. | Animal Model: | 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | I.p.; twice daily for 3 days | | Result: | Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex. |
| [storage]
Desiccate at RT |
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