| Identification | Back Directory | [Name]
GP ANTAGONIST-2A | [CAS]
89430-38-6 | [Synonyms]
RPKPQQDWFDWDWM
GP ANTAGONIST-2A
[D-TRP7,9,10]-SUBSTANCE P
Substance P, [D-Trp7,9,10]
M.W. 1588.89 C79H105N21O13S
ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-D-TRP-MET-NH2
H-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-D-TRP-MET-NH2
L-Methioninamide, L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-D-tryptophyl- | [Molecular Formula]
C79H105N21O13S | [MDL Number]
MFCD00240359 | [MOL File]
89430-38-6.mol | [Molecular Weight]
1588.88 |
| Hazard Information | Back Directory | [Uses]
[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1]. | [Biological Activity]
Cell permeable: no''Primary Target
Inhibits the activation of Gq by M1-muscarinic cholinergic receptors''Product does not compete with ATP.''Reversible: no | [References]
[1] Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104. DOI:10.1016/0014-2999(85)90529-1
[2] Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243. PMID:1379592 |
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