| Chemical Properties | Back Directory | [Boiling point ]
584.4±60.0 °C(Predicted) | [density ]
1.366±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
2.50±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NOX-6-18 is a highly potent and selective GPR132 antagonist that promotes insulin secretory activity, regulates macrophage reprogramming in pancreatic islets, and reduces weight gain, and may be used as a candidate ingredient for the treatment of diabetes. | [Description]
NOX-6-18 (GPR132 antagonist 1) is a potent, selective GPR132 antagonist with IC50 of 17 nM. It modulates macrophage reprogramming within pancreatic islets, decreases weight gain, and enhances glucose metabolism in mice fed a high-fat diet. |
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