| Identification | Back Directory | [Name]
EC 3.1.1.1 | [CAS]
9013-79-0 | [Synonyms]
HLE
PLE
ESTERASE
LIPASE CA
EC 3.1.1.1
ESTERASE PL
ESTERASE RO
ESTERASE SD
ESTERASE TL
ESTERASE PF1
ESTERASE PF2
ESTERASE BS1
ESTERASE BS2
ESTERASE BS3
ESTERASE BS4
ESTERASE BS2-CLEA
CARBOXYL ESTERASE
ESTERASE (PIG LIVER)
ESTERASE ISOENZYME 1
PLE ON EUPERGIT(R) C
Carboxylesterase 1 human
CARBOXYLIC-ESTER HYDROLASE
CARBOXYLESTERASE, IMMOBILIZED
ESTERASE SOLUTION PORCINE LIVER
ESTERASE, FRACTION 1 (PIG LIVER)
ESTERASE, FRACTION 2 (PIG LIVER)
Carboxylesterase 1 isoform c human
Carboxylesterase 1 isoform b human
ESTERASE, IMMOBILIZED ON EUPERGIT(R) C
ESTERASE, IMMOBILIZED ON OXIRAN ACRYLIC BEADS
PIG LIVER ESTERASE, IMMOBILIZED ON EUPERGIT(R) C | [EINECS(EC#)]
232-773-7 | [MDL Number]
MFCD00131030 |
| Hazard Information | Back Directory | [Uses]
Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner. It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ. | [Uses]
Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies. It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies. | [General Description]
Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. | [Biochem/physiol Actions]
Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs). It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups. CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs. |
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