| Identification | Back Directory | [Name]
PROTEASOME SUBSTRATE VI, FLUOROGENIC | [CAS]
90468-18-1 | [Synonyms]
Z-ARR-AMC
Z-ARR-AMC, 2HCL
Z-ALA-ARG-ARG-AMC
Z-ALA-ARG-ARG-AMC HCL
Z-ALA-ARG-ARG-AMC HYDROCHLORIDE SALT
PROTEASOME SUBSTRATE VI, FLUOROGENIC
Z-ALA-ARG-ARG-7-AMINO-4-METHYLCOUMARIN
Z-L-ALANYL-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
N-[(Phenylmethoxy)carbonyl]-L-alanyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide | [Molecular Formula]
C33H44N10O7 | [MDL Number]
MFCD00238400 | [MOL File]
90468-18-1.mol | [Molecular Weight]
692.77 |
| Chemical Properties | Back Directory | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
DMSO: 200mg/mL
80% acetic acid: 50mg/mL
methanol: soluble | [form ]
solid | [pka]
11.13±0.46(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome[1]. | [Biological Activity]
Cell permeable: no''Primary Target
Proteasome''Product does not compete with ATP.''Reversible: no | [References]
[1] Crawford LJ, et al. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Res. 2006 Jun 15;66(12):6379-86. DOI:10.1158/0008-5472.CAN-06-0605 |
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