| Identification | Back Directory | [Name]
PHOSPHODIESTERASE II | [CAS]
9068-54-6 | [Synonyms]
PDEII
EC 3.1.16.1
IUB: 3.1.16.1
3'-exonuclease
SPLEEN EXONUCLEASE
PhosphodiesteraseⅡ
PHOSPHODIESTERASE II
EC 3.1.16.1 TYPE I-SA
EXONUCLEASE I, E COLI
3'-EXONUCLEASE TYPE I-SA
Spleen phosphodiesterase
PHOSPHODIESTERASE, TYPE II
PHOSPHODIESTERASE II TYPE I-SA
PhosphodiesteraseIiExBovineSpleen
SPLEEN PHOSPHODIESTERASE TYPE I-SA
Native Bovine Phosphodiesterase II
PhosphodiesteraseIIfrombovinespleen
phosphodiesterase ii from calf spleen
PHOSPHODIESTERASE, TYPE II, CALF SPLEEN
phosphodiesterase ii type I-sa from*bovine spleen
PHOSPHODIESTERASE II FROM BOVINE SPLEEN(10 - 15UNITS/VIAL)
POLYOXYETHYLENE (20) SORBITAN MONOLAURATE SOLUTION, 10% WATER
3μ-Exonuclease, Spleen exonuclease, Spleen phosphodiesterase
Phosphodiesterase II from bovine spleen lyophilized powder, >=5.0 units/mg protein | [EINECS(EC#)]
232-965-0 | [MDL Number]
MFCD00131884 |
| Hazard Information | Back Directory | [Uses]
The product has been used in the characterization of polynucleotide chain length, base composition, and identity of terminal nucleotide. The enzyme has also been used in excision of pyridyloxobutyl (POB) base adducts from DNA. Furthermore, it has been used along with micrococcal endonuclease to hydrolyze purified DNA to 3 -nucleoside monophosphates. | [General Description]
Phosphodiesterase (PDE) II belong to the PDE superfamily and includes subtypes from one to 11. They exists as a dimer and comprise a N-terminal regulatory domain, C-terminal prenylated domain and a Zn2+ containing catalytic domain. The bovine spleen PDE2 corresponds to a molecular weight of 65 kDa. It requires divalent cations for its enzymatic activity and has an optimum pH of 7.5. | [Biochem/physiol Actions]
Phosphodiesterase (PDE) breaks phosphodiester bonds. 3-Isobutyl-methylxanthine (IBMX) is a potential PDE2 inhibitor. |
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