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910484-28-5

910484-28-5 Structure

910484-28-5 Structure
IdentificationBack Directory
[Name]

(S)-4-(6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile
[CAS]

910484-28-5
[Synonyms]

TTA-Q6
TTAQ6,TTA Q6,TTA-Q-6
4-[(4S)-6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1H-quinazolin-4-yl]benzonitrile
(S)-4-(6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile
Benzonitrile, 4-[(4S)-6-chloro-4-cyclopropyl-1,2,3,4-tetrahydro-2-oxo-3-(2,2,2-trifluoroethyl)-4-quinazolinyl]-
[Molecular Formula]

C20H15ClF3N3O
[MDL Number]

MFCD15528951
[MOL File]

910484-28-5.mol
[Molecular Weight]

405.8
Chemical PropertiesBack Directory
[Boiling point ]

550.2±50.0 °C(Predicted)
[density ]

1.47±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (308.03 mM)
[form ]

Solid
[pka]

12.54±0.40(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Description]

TTA-Q6 is a selective antagonist of T-type Ca2+ channel and can be used in neurological research[1].

TTA-Q6 displayed good overall profiles and were examined in several in vivo assays responsive to T-type calcium channel antagonists. It showed robust inhibition of seizures in the WAG/Rij epilepsy model after oral dosing at 3 mg/kg. A 10 mg/kg dose of TTA-Q6 to rats right before their sleep period produced a further suppression of active wake for 0.5-2 h after dosing[2]. TTA-Q6 dose-dependently reduced amphetamine-induced psychomotor activity[3].

[storage]

Store at -20°C
[References]

[1]: Schlegel KA, Yang ZQ, et,al.Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52. doi: 10.1016/j.bmcl.2010.07.010. Epub 2010 Jul 8. PMID: 20673719.
[2]: Barrow JC, Rittle KE, et,al. Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists. ACS Med Chem Lett. 2010 Feb 1;1(2):75-9. doi: 10.1021/ml100004r. PMID: 24900180; PMCID: PMC4007971.
[3]: Uslaner JM, Smith SM, et,al. T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats. Neuropharmacology. 2012 Mar;62(3):1413-21. doi: 10.1016/j.neuropharm.2010.11.015. Epub 2010 Nov 24. PMID: 21110986.

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