| Identification | Back Directory | [Name]
1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester | [CAS]
911417-26-0 | [Synonyms]
911417-26-0
tert-butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)aMino)-1H-indazole-1-carboxylate
1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester | [Molecular Formula]
C26H23N5O3 | [MDL Number]
MFCD28347542 | [MOL File]
911417-26-0.mol | [Molecular Weight]
453.49 |
| Hazard Information | Back Directory | [Uses]
1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester is a valuable organic compound that could used to synthesize tert-Butyl 5-(2-(3-(2-tert-butoxy-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-lH- indazole-l-carboxylate and tert-butyl 5-(2-(3-(2-(isopropylamino)-2-oxoethoxy)-phenyl)quinazolin-4- ylamino)-lH-indazole-l-carboxylate. | [Synthesis]
To a solution of give tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-lH- indazole-l-carboxylate (5.85 g, 11.8 mmole) in anhydrous MeOH (400 mL) was added 28 % (wt/v) NH4OH solution (6.50 mL). The reaction mixture was stirred at ambient temperature for 48 h. The crude product was filtered and washed with ether followed by hexane and dried under high vacuum overnight to give tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate (1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester). |
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