ChemicalBook--->CAS DataBase List--->912-60-7

912-60-7

912-60-7 Structure

912-60-7 Structure
IdentificationBack Directory
[Name]

NOSCAPINE HYDROCHLORIDE
[CAS]

912-60-7
[Synonyms]

NOSCAPINEHCL
opianhydrochloride
capvalhydrochloride
lyobexhydrochloride
nsc5366hydrochloride
vadebexhydrochloride
NOSCAPINE BASE / HCL
NOSCAPINE EP STANDARD
opianinehydrochloride
terbenolhydrochloride
nectadonhydrochloride
longatinhydrochloride
coscopinhydrochloride
coscotabshydrochloride
narcosinehydrochloride
NOSCAPINE USP STANDARD
tusscapinehydrochloride
narcomprenhydrochloride
NOSCAPINE HYDROCHLORIDE
NARCOTINE HYDROCHLORIDE
Noscapine HCl(Nectodon)
l-Narcotine hydrochloride
key-tusscapinehydrochloride
1-alpha-narcotinehydrochloride
methoxyhydrastinehydrochloride
Narcotine HCl((S,R)-Noscapine)
NOSCAPINE HYDROCHLORIDE USP/EP/BP
Noscapine hydrate hydrochloride
Narcotine, hydrochloride (7CI, 8CI)
NoscapineHydrochlorideMonohydrate>
Noscapine hydrochloride hydrate,Narcotine hydrochloride
,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-
1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1
6,7-Dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one hydrochloride
(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranonehydrochloride
(3S)-6,7-DIMETHOXY-3-[(5R)-5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL]-1(3H)-ISOBENZOFURANONE HYDROCHLORIDE
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, hydrochloride, [S-(R*,S*)]-
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (9CI)
[EINECS(EC#)]

213-014-9
[Molecular Formula]

C22H24ClNO7
[MDL Number]

MFCD00082546
[MOL File]

912-60-7.mol
[Molecular Weight]

449.88
Chemical PropertiesBack Directory
[Appearance]

White or almost white, crystalline powder or colourless crystals, hygroscopic.
[Melting point ]

221-223 °C(lit.)
[storage temp. ]

2-8°C
[solubility ]

Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
[form ]

neat
[color ]

Crystals
[Merck ]

13,6752
[EPA Substance Registry System]

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)
Hazard InformationBack Directory
[Chemical Properties]

White or almost white, crystalline powder or colourless crystals, hygroscopic.
[Uses]

Anti-Tussive
[Uses]

topical fluoroquinolone antibiotic for acne
[Biological Activity]

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
[Safety Profile]

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

22
[Safety Statements ]

36
[RIDADR ]

1544
[WGK Germany ]

3
[RTECS ]

NP7225000
[F ]

10
[HS Code ]

2939.19.5000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[Toxicity]

cyt-ham:fbr 60 mg/L ESKHA5 96,55,78
Spectrum DetailBack Directory
[Spectrum Detail]

NOSCAPINE HYDROCHLORIDE(912-60-7)1HNMR
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