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913723-61-2

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913723-61-2 Structure

913723-61-2 Structure
IdentificationBack Directory
[Name]

Cl-Amidine
[CAS]

913723-61-2
[Synonyms]

Cl-Amidine
N-alpha-Benzoyl-N5-(2-chloro-1-iminoethyl)-1-ornithine amide
N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide
Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-
N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamideN-
[Molecular Formula]

C14H19ClN4O2
[MDL Number]

MFCD20278255
[MOL File]

913723-61-2.mol
[Molecular Weight]

310.78
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P280-P305+P351+P338
Hazard InformationBack Directory
[Definition]

ChEBI: Cl-Amidine is a member of benzenes.
[Biological Activity]

Cl-amidine is an orally active PAD inhibitor with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3 and PAD4, respectively.It induces apoptosis in cancer cells. And Cl-Amidine blocks histone 3 citrullination and neutrophil extracellular trap formation and improves survival in mice with sepsis.
[target]

IC50: 0.8 μM (PAD1), 5.9 μM (PAD4), 6.2 μM (PAD3).

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