| Identification | Back Directory | [Name]
H-1152Glycyl, Dihydrochloride | [CAS]
913844-45-8 | [Synonyms]
Glycyl-H 1152 2HCl
Rho Kinase Inhibitor IV
H-1152Glycyl, Dihydrochloride
(S)-Glycyl-H-1152 (hydrochloride)
(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
(2S)-4-(Aminoacetyl)hexahydro -2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride
2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride | [Molecular Formula]
C18H26Cl2N4O3S | [MDL Number]
MFCD09971082 | [MOL File]
913844-45-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale-Yellow Solid | [Melting point ]
190-192°C | [storage temp. ]
Refrigerator | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Beige | [Stability:]
Hygroscopic | [CAS DataBase Reference]
913844-45-8 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale-Yellow Solid | [Uses]
A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis. | [Biological Activity]
Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride ((S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride ) that displays improved ROCKII selectivity. IC 50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μ M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Wuhan Topule
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+86-02787215551 +86-19945035818 |
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http://www.topule.com/ |
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