| Identification | Back Directory | [Name]
Methotrexate | [CAS]
91431-42-4 | [Synonyms]
RS4317
RS-43197
RS 43179
Lopalene
Lonapalene
RS4317 (Lonapalene)
6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate
1,4-Naphthalenediol, 6-chloro-2,3-dimethoxy-, 1,4-diacetate | [Molecular Formula]
C16H15ClO6 | [MOL File]
91431-42-4.mol | [Molecular Weight]
338.74 |
| Chemical Properties | Back Directory | [Melting point ]
93-94° (Jones); mp 87.5-89.5° (Perri, Moore) | [Boiling point ]
424.9±45.0 °C(Predicted) | [density ]
1.309±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Originator]
Lonapalene,Syntex | [Uses]
Antipsoriatic. | [Definition]
ChEBI: Lonapalene is an organochlorine compound and a member of naphthalenes. | [Manufacturing Process]
A solution of sodium nitrate (0.69 g, 10 mmol) in water (5 ml) was added at
0-5°C to a solution of 6-amino-2,3-dimethoxy-1,4-naphthoquinone (1.17 g, 5
mmol) in 5:1 acetic acid:water (25 ml) containing concentrated hydrochloric
acid (1.7 ml). A further quantity of sodium nitrite (0.69 g) was then added to
the reaction mixture after cooling to -5°C, followed by a solution of cuprous
chloride (0.6 g) in concentrated hydrochloric acid (5 ml). The mixture was
allowed to warm to room temperature and solid cuprous chloride was added
portionwise until the mixture assumed a green color. Water was then added to
the reaction mixture and the precipitated yellow solid filtered off, washed with
water and recrystallized from methanol:water (2:1) giving 1.01 g of 6-chloro-
2,3-dimethoxy-1,4-naphthoquinone, melting point 93-94°C (from etherpetrolium ether). | [Therapeutic Function]
Antipsoriatic |
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