| Identification | Back Directory | [Name]
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide | [CAS]
918505-61-0 | [Synonyms]
CS-1029
PLX 4032
INXN-1001
ZELBORAF.(R).
BRAF inhibitor
PLX-4032(RG7204)
Vemurafenib-Analog
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin...
N-(2,4-Difluoro-3-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]-pyridine-3-carbonyl)phenyl)propane-2-sul
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-2-propanesulfonamide
N-(2,4-Difluoro-3-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]-pyridine-3-carbonyl)phenyl)propane-2-sulfin
N-(2,4-Difluoro-3-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-2-sulfinamide
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide
2-PropanesulfonaMide, N-[2,4-difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]- | [Molecular Formula]
C22H18F2N4O3S | [MDL Number]
MFCD16659048 | [MOL File]
918505-61-0.mol | [Molecular Weight]
456.47 |
| Chemical Properties | Back Directory | [density ]
1.45 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (109.54 mM; Need ultrasonic) | [form ]
Powder | [pka]
6.54±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor |
|
|