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ChemicalBook--->CAS DataBase List--->919767-02-5

919767-02-5

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919767-02-5 Structure

919767-02-5 Structure
IdentificationBack Directory
[Name]

KRN383
[CAS]

919767-02-5
[Synonyms]

KRN383
[Molecular Formula]

C17H17N3O4
[MDL Number]

MFCD28138417
[MOL File]

919767-02-5.mol
[Molecular Weight]

327.33
Hazard InformationBack Directory
[Description]

KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies.
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