| Identification | Back Directory | [Name]
α-GalCer analog 8 | [CAS]
922727-14-8 | [Synonyms]
α-GalCer analog 8
α-GalCer analog 8
α-Galactosylceramide analog 8 | [Molecular Formula]
C50H97N3O8 | [MOL File]
922727-14-8.mol | [Molecular Weight]
868.34 |
| Hazard Information | Back Directory | [Description]
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.1 It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 μg per animal dose, indicating a Th2 response. | [References]
1. Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer J. Med. Chem. 50(3),585-589(2007). |
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