| Identification | Back Directory | [Name]
ABP688 | [CAS]
924298-51-1 | [Synonyms]
ABP688
ABP 924298-51-1
3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
2-Cyclohexen-1-one, 3-[2-(6-methyl-2-pyridinyl)ethynyl]-, O-methyloxime | [Molecular Formula]
C15H16N2O | [MDL Number]
MFCD17018722 | [MOL File]
924298-51-1.mol | [Molecular Weight]
240.3 |
| Chemical Properties | Back Directory | [Boiling point ]
361.4±52.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mM | [form ]
A solid | [pka]
2.78±0.19(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
ABP 688 is a high affinity and selective of metabotropic glutamate receptor (mGluR5). Also, it inhibits glutamate induced calcium release from L(tk-) cells expressing human mGlu5 receptors. | [Enzyme inhibitor]
This high-affinity mGluR antagonist (FW = 240.31 g/mol; CAS 924298- 51-1; Soluble to 100 mM in DMSO; 50 mM in 1 eq. HCl), also named 3- [2-(6-methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime, targets the human metabolotrophic glutamate receptor-5 (mGluR5) (Ki = 1.7 nM) and inhibits glutamate-induced calcium release from Ltk-cells expressing human mGlu5 receptors (IC50 = 2.3 nM). Indeed, [11C]- ABP688 is a useful PET tracer for in vivo imaging of the mGluR5 in rodents. | [storage]
Store at -20°C |
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