| Identification | Back Directory | [Name]
BT 18 | [CAS]
924811-53-0 | [Synonyms]
BT 18
Methanone, [4-[5-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)sulfonyl]-2-methoxyphenyl]-1-piperazinyl][4-fluoro-2-(trifluoromethyl)phenyl]- | [Molecular Formula]
C30H31F4N3O6S | [MDL Number]
MFCD19950816 | [MOL File]
924811-53-0.mol | [Molecular Weight]
637.64 |
| Hazard Information | Back Directory | [Biological Activity]
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells[1]. | [References]
[1]. Leo Jakman, Characterization of small-molecule GDNF mimics.[2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414. |
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