| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:2.0(Max Conc. mg/mL);5.46(Max Conc. mM)
DMSO:3.0(Max Conc. mg/mL);8.19(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);13.65(Max Conc. mM) |
| Hazard Information | Back Directory | [Description]
HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 μM, respectively). It also inhibits PKC and blocks intracellular calcium mobilization. HA-1004 induces relaxation of isolated rabbit aortic strips precontracted with histamine, serotonin , A23187 , angiotensin II , or prostaglandin F2α (; EC50s = 0.32-0.63 μM), as well as phenylephrine (Item Nos. 18619 | 17205) with or without calcium (EC50s = 2.3 and 0.5 μM, respectively). It also inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure when administered intratracheally at a dose of 0.1 mg per animal. | [storage]
Store at -20°C |
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